Formulation and Evaluation of Atorvastatin Calcium Loaded Nanosponges By Emulsion Solvent Diffusion Method

Selvamuthukumar R, Sanjayraj S, Arunkumar R, Balamurugan, Saminathan C

Objective: The objective of the present study was to formulate Atorvastatin calcium loaded Nanosponges by emulsion solvent diffusion method and aimed to increase its bioavailability of the drug. Methods: The Atorvastatin calcium loaded Nanosponges was prepared by emulsion solvent diffusion method using different drug-polymer ratios (1:0.5 to 1:3) ethyl cellulose is used as a polymer. Fourier transform infrared spectroscopy (FT-IR) estimated the compatibility of Atorvastatin calcium with polymer. All formulations evaluated for percentage yield, drug entrapment efficiency, in-vitro drug release, scanning electron microscopy (SEM). Results: The FT-IR studies revealed that no interaction between drug and polymer. The percentage yield of all batches in the range of 66.66% to 89.33%, the entrapment efficiency of all batches in the range of 67.33% to 87.16%. The average particle size ranges from 213 to 512 nm. By the end of 12th hour F II formulation shows highest drug release was found to be 94.9 %. The release kinetics of the prepared Nanosponges shows zero-order drug release. Conclusion: The results of various evaluation parameters, revealed that Atorvastatin calcium Nanosponges would be possible delivery systems to conventional formulation to improve its bioavailability, the emulsion solvent diffusion method was simple and best method for preparation of Nanosponges.

Keywords: Nanosponges, Atorvastatin calcium, Emulsion solvent diffusion method.